Ritable: Pedigree-Based Heritability Estimation for Family Cohort Studies

Provides profile-likelihood variance-components estimation of narrow-sense heritability (h2) for quantitative traits in family cohort studies. Additive genetic relationship matrices are built from pedigrees via 'kinship2'. Phenotypes are inverse-normal transformed internally. Likelihood-ratio tests use a one-sided chi-squared boundary correction equivalent to SOLAR Eclipse. Ninety-five percent confidence intervals are derived from the profile likelihood rather than Wald approximations. Batch estimation over many traits returns tidy data frames ready for downstream visualisation (forest plots, heatmaps).

See also

Useful links:

• https://r-itable.circadia-lab.uk

• https://github.com/circadia-bio/R-itable

• Report bugs at https://github.com/circadia-bio/R-itable/issues

Author

Maintainer: Lucas França lucas.franca@northumbria.ac.uk (ORCID)

Authors:

• Lucas França lucas.franca@northumbria.ac.uk (ORCID)

• Mario Leocadio-Miguel mario.miguel@northumbria.ac.uk (ORCID)