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Genetic relationship matrix

Build the additive GRM (and household matrix) from a pedigree data frame.

build_grm()
Build an additive genetic relationship matrix from a pedigree
build_household()
Build a household (shared-environment) indicator matrix

Heritability estimation

Single-trait and batch profile-likelihood VC estimation.

herit_vc()
Profile-likelihood variance-components heritability estimation
herit_batch()
Batch heritability estimation over multiple traits

Household effects & twin ACE models

A vs C identifiability for family and twin cohorts.

herit_ace()
A vs C identifiability check (ACE model comparison)

Bivariate genetic/environmental correlation

Genetic and environmental correlation between trait pairs.

herit_bivar()
Bivariate genetic and environmental correlation between two traits
herit_bivar_batch()
Batch bivariate genetic/environmental correlations with FDR correction

Utilities

Helper functions used internally and exported for pipelines.

int_transform()
Inverse-normal (rank-based) transformation
Ritable_colours
R-itable colour palette

Visualisation

Forest plots for heritability results.

plot_forest()
Forest plot of heritability estimates

Package

Package-level documentation.

Ritable Ritable-package
Ritable: Pedigree-Based Heritability Estimation for Family Cohort Studies